Indeed, the collapse extends beyond serotonin, encompassing similar lack of evidence for specific imbalances in other neurotransmitter systems like norepinephrine or dopamine as primary causes of complex mental health conditions. This scientific void for localized chemical deficits significantly strengthens frameworks that emphasize global brain dynamics, such as the field dysregulation framework, which views mental illness as emerging from disordered coherent field configurations rather than discrete chemical deficiencies. The observed, often modest, effects of antidepressants are increasingly understood not as rectifying a "chemical imbalance," but rather as non-specific phenomena. These include potent placebo effects, generalized emotional blunting, or minor, indirect modulations of brain activity, which are far removed from targeting a specific, measurable neurochemical deficit.